The CRGGH has developed multiple genetic epidemiology projects in the United States, Africa (Nigeria, Ghana, Kenya, and Ethiopia), and China. As a result of the successful implementation of these multi-national and multi-institutional collaborations, we currently have clinical/phenotypic data on over 10,000 people and ~70,000 biological (plasma, serum, DNA, urine and tissue) samples.
- Howard University Family Study (HUFS)
The Howard University Family Study is a genetic epidemiology study of African Americans from the Washington DC metropolitan area. Phase I of the HUFS aimed to enroll a randomly ascertained population-based cohort of 350 African American (AA) families with a minimum of five people per family. Families were not selected based on any phenotype, making it possible to investigate the genetic and environmental basis of multiple traits. Phase II enrolled unrelated African Americans (AAs) from the same communities to facilitate the conduct of genome-wide association studies. Data generated from this cohort includes: multiple cardiometabolic phenotypes, genotypes from the Affymetrix Genome-Wide Human SNP 6.0 array, exome array genotypes, targeted dense SNP genotypes on selected genomic regions, and whole exome sequence data.
- The Africa America Diabetes Mellitus (AADM) Study
The Africa America Diabetes Mellitus (AADM- pronounced Adam) is the longest running genetic epidemiology study of type 2 diabetes in Africa. The purpose of this project is to map Type 2 Diabetes (T2D) genes in West Africa, the geographical origin of most African Americans. The initial phase of the project enrolled 991 individuals with T2D (400 affected sib-pairs and 191 controls) from two centers in Ghana and three centers in Nigeria for genome-wide linkage analysis. Subsequent phases supported the recruitment of extended pedigrees of the affected sibling pairs as well as controls resulting in a larger (n > 3,600) sample size. The resources that have been generated on this sample includes: multiple cardiometabolic phenotypes, genotypes from the Affymetrix Axiom PanAFR array, exome array genotypes from the Affymetrix Exome 319 array, genome-wide and targeted microsatellite (STR) data, dense genotypes on selected genomic regions, and whole exome sequence data.
- The Genetics of T2D and Related Complications in China
This genetic epidemiology study of T2D project in China was designed to enroll well-characterized T2D cases and controls in Suizhou, China. Approximately 1,500 cases of T2D and 1,500 controls have been enrolled and characterized for our standard panel of clinical and anthropometric variables, laboratory assays on multiple biochemical parameters and diabetes-related complications. Exome array data has been generated on this genotype.
Software/Code and Other Resources
Chen G, Yuan A, Zhou Y, Bentley AR, Zhou J, Chen W, Shriner D, Adeyemo A, Rotimi CN. Simultaneous Analysis of Common and Rare Variants in Complex Traits: Application to SNPs (SCARVAsnp). Bioinform Biol Insights, 6:177-185. 2012. [PubMed]
- Corrected Tracy-Widom Test
Shriner D. Improved Eigenanalysis of Discrete Subpopulations and Admixture Using the Minimum Average Partial Test. Hum Hered, 73:73-83. 2012. [PubMed]
Shriner D, Tekola-Ayele F, Adeyemo A, Rotimi CN. Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry. Sci Rep 4:6055. 2014. [PubMed]
- Projection Analysis
Baker JL, Rotimi CN, Shriner D. Human ancestry correlates with language and reveals that race is not an objective genomic classifier.
Last Updated: January 17, 2017